¡ÁÉ÷¼Ù¤ò¤Ò¤¤¤Æ¤¤¤ë»þ¤ÏÅ´ºÞ¤Ï°û¤Þ¤Ê¤¤¡Á ¡ÚÈùÀ¸Êª¤È¥·¥Ç¥í¥Õ¥©¥¢¡ÛDr.±üÊ¿¤Î±ÉÍÜ´ÁÊý¼£ÎŹֺ¡ãÅ´¡ä
JUGEM¥Æ¡¼¥Þ¡§¿©»ö¡¦±ÉÍÜÎÅË¡
¡ÁÉ÷¼Ù¤ò¤Ò¤¤¤Æ¤¤¤ë»þ¤ÏÅ´ºÞ¤Ï°û¤Þ¤Ê¤¤¡Á
¡ÚÈùÀ¸Êª¤È¥·¥Ç¥í¥Õ¥©¥¢¡Û
Fe3¡Ü¥¤¥ª¥ó¤Ï¸µÍè¿å¤ËÍϤ±¤Ë¤¯¤¤¤Ç¤¹¤¬¡¤¤µ¤é¤ËÓ®ÆýÎà¤Î·ì±ÕÃæ¤Ë¤ÏÅ´¤È·ë¹ç¤·¤Æ¤¤¤Ê¤¤ÉÔË°Ï¥ȥé¥ó¥¹¥Õ¥§¥ê¥ó¡Êʬ»ÒÎÌ 80 kDa¡Ë¤¬Â¸ºß¤·¡¤¼÷Ì¿¤ò½ª¤¨¤¿ÀÖ·ìµå¤Î½èÍý¤äÁÈ¿¥¾ã³²¤Ê¤É¤Ëȼ¤Ã¤Æ·ìÃæ¤ËÊü½Ð¤µ¤ì¤ëFe3¡ÜÇ»ÅÙ¤òÄ㤯ÊݤÁ¡¤É¸¶ÀÈùÀ¸Êª¤ÎÁý¿£¤òͽËɤ·¤Æ¤¤¤Þ¤¹£³¡Ë¡¥
¤µ¤é¤Ë´¶À÷¾É¤äËýÀ±ê¾ÉÀ¼À´µ¤Ë¤ª¤¤¤Æ¤ÏÌÖÆâ·Ï¡Ê¥Þ¥¯¥í¥Õ¥¡¡¼¥¸¡Ë¤Ë¥Õ¥§¥ê¥Á¥ó¤Î·Á¤ÇÅ´¤¬Ãù¢¤µ¤ì¡¤·ìÀ¶Å´Ç»ÅÙÄãÃͤòȼ¤¦ÉÏ·ì¤òÄ褷¤Þ¤¹¡Êanemia of chronic disease¡Ë¡¥
¤³¤ÎÉÂÂ֤Ϸì±ÕÃæ¤Ç¤ÎºÙ¶Ý¤ÎÁý¿£¤òÍÞÀ©¤¹¤ë¤¿¤á¤Ë¹çÍýŪ¤ÊÀïά¤Ç¤¢¤ê¡¤´Î¡¤«¤éʬÈ礵¤ì¤ë¥Ø¥×¥·¥¸¥ó¤ÎÁý²Ã¤¬½ÅÍפÊÌò³ä¤ò²Ì¤¿¤·¤Æ¤¤¤Þ¤¹£´¡Ë¡¥
¤·¤¿¤¬¤Ã¤Æ¡¤´¶À÷¾É¤ÎµÞÀ´ü¤Ç´¶À÷¤Î¥³¥ó¥È¥í¡¼¥ë¤¬¤Ç¤¤Æ¤¤¤Ê¤¤»þ¤Ë¤ÏÅ´ºÞ¤ÎÅêÍ¿¤ò¸«¹ç¤ï¤»¤ëɬÍפ¬¤¢¤ê¤Þ¤¹¡¥
¥Õ¥§¥ê¥Á¥ó¤Ï 24 ¸Ä¤Î¥µ¥Ö¥æ¥Ë¥Ã¥È¤«¤é¤Ê¤ë 500 kDa¤ÎÂç·¿ÃÁÇò¤Ç¡¤1 ʬ»Ò¤Î¥Õ¥§¥ê¥Á¥ó¤Ï 4,000 ¸Ä¤â¤ÎFe3¡Ü¥¤¥ª¥ó¤ò·ë¹ç¤·¡¤ºÙ˦¼ÁÆâ¤Ë;¾êÅ´¤òÃù¢¤¹¤ë¤³¤È¤¬¤Ç¤¤Þ¤¹¡¥
¥·¥Ç¥í¥Õ¥©¥¢¤ÏÅ´·ç˳¤Ë±þÅú¤·¤ÆºÙ¶Ý¤Ê¤É¤«¤éʬÈ礵¤ì¤ëÅ´·ë¹çÀ¡¤Èó¥Ú¥×¥Á¥ÉÀ¤Î¾®Ê¬»Ò¤Ç¡¤¤½¤Îʬ»ÒÎÌ¤Ï 1,000 Da°Ê²¼¤Ç¤¹¡¥
¥·¥Ç¥í¥Õ¥©¥¢ ¤ÎÅ´¤ËÂФ¹¤ë·ë¹çÎϤÏÃø¤·¤¯¶¯¤¤¤¿¤á¡¤Ó®ÆýÎà¤Ê¤É¤Î½É¼ç¤ÎÂÎÆâ¤Ë¸ºß¤¹¤ë¥È¥é¥ó¥¹¥Õ¥§¥ê¥ó¡¤¥Õ¥§¥ê¥Á¥ó¡¤¥Ø¥à¤Ê¤É¤ÎÅ´·ë¹çÀʬ»Ò¤«¤éÅ´¤ò°ú¤剝¤¬¤·¤Æ¡¤ºÙ¶Ý¤ËÅ´¤ò¶¡µë¤Ç¤¤Þ¤¹£³¡Ë¡¥
ÈùÀ¸Êª¤ä¿¢Êª¤Î»ºÀ¸¤¹¤ë¥·¥Ç¥í¥Õ¥©¥¢¤Î¼ïÎࡤ¹½Â¤¤Ï¿´ô¤Ë¤ï¤¿¤Ã¤Æ¤ª¤ê¡¤¤¹¤Ç¤Ë¿ôÉ´¼ïÎà°Ê¾å¤¬¸«¤Ä¤«¤Ã¤Æ¤¤¤Þ¤¹£µ¡Ë¡¥
Å´¤ÎÃí¼ÍÍÑ¥¥ì¡¼¥ÈÌô¤È¤·¤ÆÎ×¾²±þÍѤµ¤ì¤Æ¤¤¤ëdesferrioxamine ¡ÊDFO¡Ë¤ÏÊüÀþ¶Ý¤Î»ºÀ¸¤¹¤ë¥·¥Ç¥í¥Õ¥©¥¢¤Ç¡¤ÉûºîÍѤȤ·¤ÆDFO¤òÍøÍѤǤ¤ë¥¨¥ë¥·¥Ë¥¢¶Ý¤ä¥à¥³¡¼¥ë¿¿¶Ý¤Ë¤è¤ë´¶À÷¾É¤¬ÃΤé¤ì¤Æ¤¤¤Þ¤¹¡¥
°ð¤Ï¸µÍ襷¥Ç¥í¥Õ¥©¥¢¤ò»ºÀ¸¤¹¤ëǽÎϤ¬Ä㤯¡¤¥¢¥ë¥«¥êÀ¤ÇÅ´¤òÍøÍѤ·¤Å¤é¤¤ÅÚÃϤǤÏÀ¸°é¤¬°¤¤¤Ç¤¹¤¬¡¤¥·¥Ç¥í¥Õ¥©¥¢¹çÀ®¹ÚÁǤòƳÆþ¤·¤¿°äÅÁ»Ò²þÊѺîʪ¤Ï¤½¤Î¤è¤¦¤Ê´Ä¶¤Ç¤â¤è¤¯°é¤Á¤Þ¤¹£¶¡Ë¡¥
ÂçIJ¶Ý¤Ç¤Ï¥·¥Ç¥í¥Õ¥©¥¢¤Î¹çÀ®¹ÚÁÇ 6 ¼ïÎà¡ÊEntA¤«¤é EntF¡Ë¡¤¼è¤ê¹þ¤ß¤ËɬÍפÊÃÁÇò 8 ¼ïÎà¡ÊFepA ¤Ê¤É¡Ë¤¬Æ±Äꤵ¤ì¤Æ¤¤¤Þ¤¹£·¡Ë¡¥
¥·¥Ç¥í¥Õ¥©¥¢ ¤ÏFe3¡Ü¥¤¥ª¥ó¤È·ë¹ç¤¹¤ë¤³¤È¤ÇµÛ¸÷ÇÈŤËÊѲ½¤òÍ褿¤·¡¤Æù´ãŪ¤Ë¤â¿§ºÌÊѲ½¤È¤·¤Æǧ¼±¤µ¤ì¤Þ¤¹¡¥
ÎÐÇ¿¶Ý¤ÏÎп§¿§ÁǤΤۤ«¤Ë¥·¥Ç¥í¥Õ¥©¥¢¤Î°ì¼ï¤Ç¤¢¤ë¥Õ¥ë¥ª¥ì¥»¥¤¥ó¤È¤¤¤¦·Ö¸÷¿§ÁǤòʬ È礷¤Þ¤¹¤¬¡¤¤³¤ì¤Ï¸½ºß¡¤·Ö¸÷´ãÄ측ºº¡¤·Ö¸÷À÷¿§¡¤ÆþÍáºÞ¤Ê¤É¤Ë±þÍѤµ¤ì¤Æ¤¤¤Þ¤¹¡¥
3¡ËRatledge C, et al: Iron metabolism in pathogenic bacteria. Annu Rev Microbiol 54 : 881¡½941, 2000.
4¡ËÀ¸ÅĹîºÈ¡¤Â¾¡§Å´Âå¼Õ¤Ë¤ª¤±¤ë¥Ø¥×¥·¥¸¥ó¤Îµ¡Ç½¡¥Î×¾² ·ì±Õ 48 : 36¡½45, 2007.
ÆüÆâ²ñ»ï 99¡§1188¡Á1193¡¤2010
¢¡±üÊ¿ÃÒÇ·FB¥°¥ë¡¼¥×
¢¡±üÊ¿ÃÒÇ·Ãø½ñ
¡¡¥Þ¥ó¥¬¤Ç¤ï¤«¤ë ¥³¥³¥í¤ÎÉÔÄ´²óÉü ¿©¤Ù¤Æ¤¦¤Ä¤Ì¤±
¡¡Ã±¹ÔËÜ¡Ê¥½¥Õ¥È¥«¥Ð¡¼¡Ë – 2017/11/11
¡¡±üÊ¿ ÃÒÇ· (Ãø), ¤¤¤·¤¤¤Þ¤ (¥¤¥é¥¹¥È)¡¡¡¡
- 2018.03.10 Saturday
- Dr.±üÊ¿¤Î±ÉÍÜ´ÁÊý¼£ÎŹֺ¡ãÅ´¡ä
- 07:00
- comments(0)
- -
- by ¿©¤Ù¤Æ¤¦¤Ä¤Ì¤±