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    Å´¤ÎÃí¼ÍÍÑ¥­¥ì¡¼¥ÈÌô¤È¤·¤ÆÎ×¾²±þÍѤµ¤ì¤Æ¤¤¤ëdesferrioxamine ¡ÊDFO¡Ë¤ÏÊüÀþ¶Ý¤Î»ºÀ¸¤¹¤ë¥·¥Ç¥í¥Õ¥©¥¢¤Ç¡¤ÉûºîÍѤȤ·¤ÆDFO¤òÍøÍѤǤ­¤ë¥¨¥ë¥·¥Ë¥¢¶Ý¤ä¥à¥³¡¼¥ë¿¿¶Ý¤Ë¤è¤ë´¶À÷¾É¤¬ÃΤé¤ì¤Æ¤¤¤Þ¤¹¡¥

    °ð¤Ï¸µÍ襷¥Ç¥í¥Õ¥©¥¢¤ò»ºÀ¸¤¹¤ëǽÎϤ¬Ä㤯¡¤¥¢¥ë¥«¥êÀ­¤ÇÅ´¤òÍøÍѤ·¤Å¤é¤¤ÅÚÃϤǤÏÀ¸°é¤¬°­¤¤¤Ç¤¹¤¬¡¤¥·¥Ç¥í¥Õ¥©¥¢¹çÀ®¹ÚÁǤòƳÆþ¤·¤¿°äÅÁ»Ò²þÊѺîʪ¤Ï¤½¤Î¤è¤¦¤Ê´Ä¶­¤Ç¤â¤è¤¯°é¤Á¤Þ¤¹£¶¡Ë¡¥

    ÂçIJ¶Ý¤Ç¤Ï¥·¥Ç¥í¥Õ¥©¥¢¤Î¹çÀ®¹ÚÁÇ 6 ¼ïÎà¡ÊEntA¤«¤é EntF¡Ë¡¤¼è¤ê¹þ¤ß¤ËɬÍפÊÃÁÇò 8 ¼ïÎà¡ÊFepA ¤Ê¤É¡Ë¤¬Æ±Äꤵ¤ì¤Æ¤¤¤Þ¤¹£·¡Ë¡¥

    ¥·¥Ç¥í¥Õ¥©¥¢ ¤ÏFe3¡Ü¥¤¥ª¥ó¤È·ë¹ç¤¹¤ë¤³¤È¤ÇµÛ¸÷ÇÈŤËÊѲ½¤òÍ褿¤·¡¤Æù´ãŪ¤Ë¤â¿§ºÌÊѲ½¤È¤·¤Æǧ¼±¤µ¤ì¤Þ¤¹¡¥

    ÎÐÇ¿¶Ý¤ÏÎп§¿§ÁǤΤۤ«¤Ë¥·¥Ç¥í¥Õ¥©¥¢¤Î°ì¼ï¤Ç¤¢¤ë¥Õ¥ë¥ª¥ì¥»¥¤¥ó¤È¤¤¤¦·Ö¸÷¿§ÁǤòʬ È礷¤Þ¤¹¤¬¡¤¤³¤ì¤Ï¸½ºß¡¤·Ö¸÷´ãÄ측ºº¡¤·Ö¸÷À÷¿§¡¤ÆþÍáºÞ¤Ê¤É¤Ë±þÍѤµ¤ì¤Æ¤¤¤Þ¤¹¡¥

     

    3¡ËRatledge C, et al: Iron metabolism in pathogenic bacteria. Annu Rev Microbiol 54 : 881¡½941, 2000. 


    4¡ËÀ¸ÅĹîºÈ¡¤Â¾¡§Å´Âå¼Õ¤Ë¤ª¤±¤ë¥Ø¥×¥·¥¸¥ó¤Îµ¡Ç½¡¥Î×¾² ·ì±Õ 48 : 36¡½45, 2007.


    5¡ËRoosenberg JM 2nd, et al : Studies and syntheses of siderophores, microbial iron chelators, and analogs as potential drug delivery agents. Curr Med Chem 7 : 159¡½197, 2000. 


    6¡ËTakahashi M, et al: Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes. Nat Biotechnol 19 : 466¡½469, 2001. 


    7¡ËRaymond KN, et al: Enterobactin:an archetype for microbial iron transport. Proc Natl Acad Sci U S A 100 : 3584¡½ 3588, 2003.

     

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